| Principles of immunohaemotology: identification of blood group antigens and antibodies. Genetics, interitance, structure and role of red cell antigens. Basis of specificity. Antibody site. Antigen determinants. Comparison of Ig subclasses. The immune response: role of Bursa of Fabricu, thymus. Subsets. Autoreactive T cells. Immune torelance. Thymic selection: role of apoptosis. Instructive and selective modes of response. Complement system: Cascadeand alternative pathway. Other blood group systems: Kell, Kidd, Lewis, MNSS and others. Further studies on antibody detection and identification. Enzymes colloids, use of mono-specific reagents. Compatibility testing: selection of appropriate blood and blood components for transfusion and possible adverse effects. The incompatible X-Match. Haemolytic transfusion reactions. Blood collection: Blood component therapy, sexually transmissible diseases. Autologous transfusion. Investigation of autoimmune haemolytic diesease. Immune red cell destruction in vivo. Storage os cells at -80°C and -190°C and effects on antigens. The cell separator: blood components. Haemolytic disease of the newborn: treatment and prevention. The Human Leukocyte Antigens (HLA) and their role in tissue and organ matching for transplantation. Detection of HLA antibodies in Post-partum sera. Preparation, standardization and quality control of human and non-human blood grouping reagents. Recent development in transfusion science: safe blood supply, screening and haemovigilance. |
Administrative assistant: RAINA FERHANA HOSSENBUX
Telephone: 4037400
Email: r.hossenbux@uom.ac.mu |
