Biochemistry and physiology of connective tissues and collagen. Review calcium homeostasis. Classification, structure and function of joints. Anatomy of the upper limb: shoulder joint and the rotator cuff; the axilla and the brachial plexus; elbow joint and cubital fossa; flexor and extensor compartments of upper arm; wrist joint and hand; flexor and extensor compartments; movements of pronation and supination. Blood and nerve supply to the upper extremities. Axial skeleton and load bearing: anatomy of the vertebral column; regional variations in vertebral structure; intervertebral joints; low back pain and herniation of intervertebral disc. Anatomy of lower limb: hip joint; flexors, extensors and adductors of the hip; surgical anatomy of the femur. The knee joint; flexors and extensors of the knee. Ankle joint and movement at the ankle. The foot. Biomechanics of joint. Nerve supply to the lower limb. Blood supply to lower limb. Fracture repair. Rheumatic disorders and arthritis. Introduction to rehabilitation. Muscle contraction mechanisms and nervous control.